Vaccines are not safe. A US Supreme Court justice has stated vaccines are “unavoidably unsafe.” Written by an emergency physician, Who Can Parents Trust? takes the opposite viewpoint, sharing reasons for parents to consider vaccines as both avoidable and unsafe. Doctors often fail to report serious illnesses and deaths following vaccinations. Thus, evidence for vaccine safety cannot be verified, given that it is predicated upon such a small reporting sample. With a paucity of adverse event reports, vaccine makers and physician advocates have gotten away with using coincidence rather than consequence as explanations for autism and SIDS. Over the past thirty years, in conjunction with an escalation in vaccination numbers, millions of vaccine-related injuries have gone unreported. Consequently no one has any right assuming vaccines are safe. What’s more, parents have a right to know vaccine risks and potential benefits. If a parent or caregiver perceives risks outweigh benefit, that person has a right to say no. In this treatise, a physician seeks to build an ethical and moral case favoring reasons that parents should not trust anyone but themselves in the matter of vaccines and their children.